Jamestown, New York is located in the Chautauqua County region of Western New York state, centrally located between Buffalo, NY; Cleveland, OH; and Pittsburgh, PA. The area is conveniently accessible via Interstates 90 and 86.

From the west, take I-86 E to exit 12 for NY-60 toward Jamestown. From the north, take I-90 W to exit 59 for NY-60 toward Dunkirk/Fredonia, then take NY-60 S. From the east, take NY-17 W/Southern Tier Expy to exit 12 for NY-60 toward Jamestown. And from the south, take I-79 N to exit 178A to merge onto I-90 E toward Buffalo, then take exit 37 to merge onto I-86 E toward Jamestown, then take exit 12 for NY-60 toward Jamestown.

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